Important Twitter Account Of The Day

Hip is okay! Excuse me worry. After shemale image, please forgive! But has been praised as "! It's Legs" to the reporter's (laughs)

? Yu Darvish Translatd (@YuDarTranslated) June 15, 2012

That's from @YuDarTranslated, which takes Yu Darvish's tweets in his native language, and runs them through Google Translate for your benefit. I don't think I'll ever get tired of jokes that have to do with poor translations.

Source: http://mlb.sbnation.com/2012/6/29/3126946/important-twitter-account-of-the-day

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Google's 'first-class' Nexus 7 tablet: 4 takeaways

Come mid-July, consumers will be able to buy the $200 gadget that runs on the powerful new operating system Jelly Bean, raising the bar for Android slabs

Google finally opened the curtains to reveal its shiny new tablet, the Asus Nexus 7, at its Google I/O conference in San Francisco. The 7-inch device is the search giant's maiden entry into the tablet hardware space, which is currently dominated by Apple's iPad and littered with third-party devices running slightly tweaked versions of Android software. How does the Nexus 7 measure up? Here, four key takeaways:

1. Google's going after the Kindle Fire
Google plans to sell the Nexus 7 starting at $199 for an 8 GB version (or $249 for 16 GB), putting it in direct competition with Amazon's similarly sized budget-version $199 Kindle Fire ? not Apple's $499 iPad. The Nexus 7, which is built by Asus under Google's supervision, will run the newest version of Android, 4.1 Jelly Bean, and comes with a 1280 x 800 back-lit display, an Nvidia quad-core Tegra 3 processor, and 1 GB of of RAM. When you look at the other available products in the same price range ? Amazon's Kindle Fire, Samsung's Galaxy Tab 2 7.0 ? "everything else basically looks like crap," says JR Raphael at Computerworld. But "this thing provides a first-class tablet experience at a budget level price."?

SEE MORE: Google's new 3D maps: 4 talking points

2. The Nexus 7's quality is readily apparent
"The tablet looks and feels sturdy," says Sara Yin at PC Mag. Its lighter and more powerful than the Fire, and its "rounded, tapered edges" with a rubber matte backing give it a distinctly "sporty" feel. A Google UI designer says Jelly Bean was designed with a 7-inch display in mind, and the difference is noticeable: "The tablet performs pretty flawlessly and scrolling is buttery smooth."?

3. The tablet takes advantage of Google's strengths
I think the OS improvements are merely incremental, says Dan Gillmor at the Guardian, "but they are impressive and keep Google at least [on par] with Apple's iOS in most ways, and ahead in a few." What really makes this particular Android device "truly compelling" is the resources of Google itself: Search, maps, and more, which are all a close approximation of their more robust desktop versions. Jelly Bean's ability to do so underscores why these Nexus devices are so important: They give users "the absolute latest operating systems on excellent hardware ? and Google, not a carrier, keeps them updated."

SEE MORE: Google's 'polished' new Chromebooks: 4 key improvements

4. It's going international
Believe it or not, $199 isn't the Nexus 7's most important price point, says Vlad Savov at The Verge: It's ?159. The Nexus 7 will go on sale in? the U.K. (and Australia and Canada) ? places where it's been difficult for Amazon to eke out content deals for things like Netflix movies (which were only recently added) or U.S.-only services like Turntable.fm, which severely limits the Kindle Fire's appeal abroad. "In beating Amazon to a broader international rollout with its media tablet, Google is laying an essentially uncontested claim to three important English-speaking markets." That's the Nexus 7's real trump card.

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How to Produce a Professional Business Presentation Making Use Of

Microsoft PowerPoint is a content presentation software developed by Microsoft. Its current version is Microsoft PowerPoint 2010, which is compatible with the current windows operating systems like Windows 7 and Windows Vista. PowerPoint 2011 is the version released for MAC operating systems.

PowerPoint is a part of the Microsoft office suite of products which also includes Word, Excel and Access. Microsoft has been successfully selling this as a suite for the last 15 years with great success. The word PowerPoint was actually coined in the year 1987 when Microsoft took over the company Forethought. While it was with Forethought, the software was called Presenter. Microsoft PowerPoint has become the chosen presentation platform for most companies that are running the Windows operating system. It has totally replaced prior presentation methods including overhead projection using film slides.

PowerPoint has a number of features to present visuals aids. Images and Video clippings can be embedded on slides. The movement from one slide to another can be made more interesting by using the animation options provided by PowerPoint. Within a slide, the various elements such as the text, images and animations can be made to appear in a particular sequence and certain transition elements can also be introduced between the appearances of the various objects within the slide.

Though many new features have been added to the PowerPoint software, the basic templates containing the slides and the associated in-built slide patterns had remained the same since it was introduced by Microsoft in 1997. The number of patterns available in the slide templates though has increased to a great extent, thereby giving the customers a wide variety of slide design patterns.

Though PowerPoint has become the medium of presenting information in formal meetings, there are still some people who continue to use overhead projectors. These people actually feel that the PowerPoint software dilutes the importance of the message that is being communicated. They feel that this software can provide information at a very broad level and is difficult to use to present specific details. Hence they have decided to stick to the older method of making film slide presentation and manual drawings on white boards. But those who want to quickly transfer the message in an efficient manner; they continue to use power point software. These power point slides can ultimately be saved as ppt. files and can be distributed easily over the web.

Learn more about Business presentation or Power point alternative

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Laura W. Murphy: 'Fixing' Citizens United Will Break the Constitution

In ?Fixing Citizens United,? Professor Geoffrey Stone -- usually a friend to the First Amendment -- argues for a constitutional amendment to ?fix? the Citizens United Supreme Court decision.?Professor Stone mentions the proposal rather offhandedly, but the idea is a nuclear option.?A constitutional amendment -- specifically an amendment limiting the right to political speech -- would fundamentally ?break? the Constitution and endanger civil rights and civil liberties for generations.

First, it?s important to be clear on what Citizens United did.?The case allowed corporations and unions (including non-profit corporations like the ACLU or National Rifle Association) to spend ?general treasury? (non-political action committee) funds on political communications that are not coordinated with a campaign.?Citizens United itself has very little to do with the dreaded ?Super PACs,? which are primarily funded by individual donations.?Individuals have been allowed to spend their own money on political speech since time immemorial (or at least since adoption of the First Amendment).?Further, Citizens United has nothing to do with direct contributions to candidates, which are still totally verboten for corporations and unions and strictly limited for individuals.

With that background, here?s the proposed amendment.

In order to ensure a fair and well-functioning electoral process, Congress and the States shall have the authority reasonably to regulate political expenditures and contributions.

When Professor Stone says federal and state governments ?shall have the power to regulate political expenditures,? he means to give them the ability to place limits on, and control the content of, political speech, even when it is non-partisan and independent of a campaign.?This speech would include typical ?vote for X? ads, but would also extend to political ?issue? advertisements (?call Senator Reid and tell him to support bill Y?), documentaries by Michael Moore and other political filmmakers and probably even social media platforms like Twitter or Facebook.?The problems with such an approach are many.

The Constitution?s radical stability is its greatest strength.?The high bar for amending the Constitution -- agreement by two-thirds of both the Senate and the House (or the states), and then three-fourths of state legislatures or constitutional conventions -- exists precisely to deter ill-considered but temporarily popular amendments, which I would argue this is.?People are wary to invest resources and time in promoting or championing constitutional amendments because the chances of failure are high.?That?s why our Constitution works so well.?It?s easy to interpret broadly, but textual change requires effort and sustained support.?

Clearly cognizant of this particular concern, Professor Stone suggests that his amendment would not be unprecedented.?On the contrary, while not the first amendment responsive to a Supreme Court case, this would be the first amendment in history to limit individual, constitutionally guaranteed rights.?The four amendments he mentions as precedent all either clarified the scope of existing constitutional provisions or expanded individual rights.?For the curious, I believe the amendments he is referring to are the 11th (states can?t be sued by people in federal court), 14th (expanding equal protection and due process rights in the wake of the Civil War), 16th (federal income tax not unconstitutional) and 26th (voting age no higher than 18).

Further, although success of an amendment limiting individual rights is thankfully unprecedented, proposed amendments certainly are not.?

The ACLU has been on the (often lonely) frontline against ill-considered but temporarily popular constitutional amendments to limit civil liberties since its inception.?For 20-plus years, we?ve been fighting amendments prompted by Supreme Court decisions in United States v. Eichman and Texas v. Johnson, which held unconstitutional state and federal laws banning flag desecration.?We?ve repeatedly opposed the ?Victims? Rights Amendment,? which would unfairly limit certain due process rights, including the right to a fair trial.?And (this is the best), Republicans today are calling for an amendment repealing the 14th Amendment?s guarantee of citizenship if you are born in the United States.?Some grotesquely call it the ?anchor baby? amendment.

Now imagine a world where Stone?s proposed Citizens United amendment serves as real precedent for using the amendment process to limit rights, and both houses of Congress are two-thirds Republican (the latter is not inconceivable even in the next Congress).?Flag desecration, victims? rights and birthright citizenship amendments would just be the beginning.?Undoubtedly, you would see additional attempts to limit individual rights through the amendment process simply on the strength of the argument:?well, we did it with political speech, why not with pornography, affirmative action, voting requirements, warrantless national security surveillance or any other similarly hot-button issue??You can bet a successful Citizens United amendment would be talking point number one for groups pushing an amendment to overturn Roe v. Wade.

Reasonable minds can and should differ on the influence of ?big money? in politics.?The legal and policy questions raised by the link between concentrated wealth and political speech are numerous and complicated.?We should be discussing the health of our politics, and we should be doing more to, for instance, provide for public financing and promote transparency without quelling anonymous speech.?But if there is one thing we absolutely should not be doing, it?s tinkering with our founding document to prevent groups like the ACLU (or even billionaires like Sheldon Adelson) from speaking freely about the central issues in our democracy.?Doing so will fatally undermine the First Amendment, diminish the deterrent factor of a durable Constitution and give comfort to those who would use the amendment process to limit basic civil liberties and rights.?It will literally ?break? the Constitution.

?

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Family home Social gathering Manufacturers ? How to Identify an ...

Way more and extra moms in the present day are interested in getting keep-at-property mothers but come across it complicated economically to give up the profession they at this time have. A number of of these mothers are deciding residence functions as a career selection. That is they are hosting household functions- not attending them!

You have almost certainly been invited and have attended a lot of household functions by yourself-Avon, Tupperware, Home Interior, Pampered Chef and way more so you?re rather acquainted with how they perform.

Significantly more Alternate options and Chances

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Increase Your Revenue

A lot of girls are by means of web-based parties as health supplements to their in place bash enterprise. The key essential to a productive job in the residential home occasion home business is discovering and picking an agency that will assist you make funds. Household get together businesses commonly more often than not incentives to maximize product sales and variety of get-togethers hosted. Uncover vendors that are generous with their bonuses and incentives. Do investigation on family home party organisations prior to picking the 1 you desire to symbolize as you?ll want a single that is highly effective. You?ll also want to acquire a small business that provides superior provider, superior quality merchandise and has a wonderful popularity with the public.

Tamra Allegre concentrates on Home Party Business

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Euro 2012 Germany vs Italy: Live Report

57 mins: SUBSTITUTION: Italy's Antonio Cassano is replaced by Alessandro Diamante who is earning just his fourth cap.

52 mins: Another opening for the Germans - Ozil makes a thrusting run to the righthand touchline and pulls it back to Khedira but he's crowded out by Italian defenders.

49 mins: Great chance for Germany's captain Philipp Lahm on the edge of the area... but he blazes over! He played a lovely one-two to set the chance up.

Joachim Loew's side have started this half with more conviction but can't afford to miss too many of those if they're going to get back into this.

46 mins: Promising early run at the Italian defence from Reus, who cuts in on his left foot on the edge of the area but can only mishit a tame shot.

1949 GMT: SUBSTITUTIONS: Two changes for Germany for the second half - Miroslav Klose and Marco Reus on for Lukas Podolksi and Mario Gomez.

We're under way again in Warsaw...

1945 GMT: Just to put the 2-0 scoreline into some kind of context, my colleague Ryland James at the game in Warsaw has sent me this little nugget:

"This is the first time Germany have been behind at a European championships game since the Euo 2008 final.

"That includes 10 qualifiers, three group matches and the quarter-final win over Greece."

1936 GMT: News from Berlin -- AFP's Raphaelle Logerot in the fan zone at the Brandenburg Gate: "Some German fans have stood up and walked out of the zone, disgusted by that second goal from Balotelli."

45 +2 mins: HALF-TIME Germany 0 Italy 2

36 mins: GOAL! Germany 0 Italy 2 - a screamer from Balotelli and Italy have doubled their lead!

A simple ball over the top from Montolivo splits the two German centre-backs and picks out Balotelli, who bears down on goal leaving Philipp Lahm in his wake before lashing a vicious shot past a stationary Manuel Neuer.

Joachim Loew on the Germany bench looks shell-shocked.

YELLOW CARD - Balotelli was booked for taking off his shirt to celebrate the goal but I doubt he's too bothered after that pearler...

34 mins: Big chance for Italy to make it 2-0... but Montolivo's wasted it! Cassano found him with a cunning pass into the area but he tries to cut onto his right foot rather than shooting first time with his left and is tackled.

28 mins: Italy are getting a good deal of possession in midfield - Pirlo is central to some tidy passing moves as he was against England in the quarter-final.

Forgot to mention that Lukas Podolski has come back into Germany's starting line-up on the left wing at the expense of Bayer Leverkusen's Andre Schuerrle, who played in their 4-2 win over Greece in last Friday.

26 mins: Powerful centre-forward play from Germany's Mario Gomez, winning a long ball which he controls and rolls to Mesut Ozil only to see the midfielder fire in a tame shot that doesn't trouble Buffon.

20 mins: GOAL! Germany 0 Italy 1 - a towering header from Balotelli and Italy are in front!

Italy worked it well down the left, Antonio Cassano beat two defenders before getting a good cross to Balotelli in the middle who rose highest to power a header home from six yards out.

Simple but deadly.

12 mins: Sami Khedira passes it out to Jerome Boateng on the right, who whips in a low cross and Buffon can only fumble it awkwardly against defender Andrea Barzagli - he is relieved to see the ball roll just past his righthand post.

More early uncertainty from the veteran Italian shot-stopper.

Bayern Munich midfielder Toni Kroos fires in a powerful shot from the resulting corner that Buffon parries away.

10 mins: A reminder that Germany have won their last 15 competitive games, a new world record according to UEFA. So the Italians are going to have to spring a real shock to get past them...

6 mins: Nervous moments for Italy there though - a corner is whipped in from the left and Mats Hummels knees it towards goal. It beats 'keeper Gianluigi Buffon but Andrea Pirlo is on the post to clear it. Lucky escape!

3 mins: Riccardo Montolivo steals possession in the Germany half and tries to slips it through to Mario Balotelli - but it's just out of the striker's reach in the area... Promising opening for the Italians.

1847 GMT: KICK-OFF: We're under way in Warsaw...

1844 GMT: Both captains, Gianluigi Buffon and Phillippe Lahm talk to the fans over the PA about the importance of UEFA's 'Respect Diversity' message, which is received to resounding applause.

1840 GMT: Both sets of players have filed out and are lined up for the national anthems - Italy's tub-thumping one first, 'Il Canto degli Italiani'...

1830 GMT: "As soon as he came onto the pitch, Mario Balotelli went over the corner of the stadium where his friends - and his brother Enoch - are sitting to greet them," my colleague Emmanuel Barranguet writes from the National Stadium.

Balotelli has friends? Remarkable.

1820 GMT: ...and this has just landed from AFP reporter Laurent Geslin in Berlin: "The atmosphere is building around the famous Brandenburg Gate as small groups of swap opinions about the upcoming match as a few beers are sunk.

"Germany's fans seem certain that 'Die Mannschaft' are going to win... 'You have to be optimistic and ignore the statistics which point to an Italian victory,' says Dennis Schiller a 25-year-old Berlin-born entrepreneur, referring to the surprising fact that Germany have yet to beat Italy in seven meetings at major championships.

'Tonight it's Germany's turn as they have the better team - we've never had such a good team.'

1810 GMT: My colleague Fran?oise Kadri has sent me this little snippet about the atmosphere that's building among fans in Rome's Piazza del Popolo (or People's Square): "There are already hundreds of (exclusively) Italian supporters, mostly young men, getting excited in the build-up to kick-off.

"We're in the middle of a heat wave here and it's nearly thirty degrees at 8pm local time! There are lots of trumpets, Italian flags being waved and faces -- not to mention several torsos - painted in the red white and green of Italy..."

1804 GMT: The starting line-ups for the game are in - it looks like Mario Gomez has reclaimed his striker's spot from Miroslav Klose while Toni Kroos also comes in:

Germany (4-2-3-1)

Manuel Neuer; Jerome Boateng, Mats Hummels, Holger Badstuber, Philipp Lahm (capt); Sami Khedira, Bastian Schweinsteiger; Lukas Podolski, Mesut Ozil, Toni Kroos; Mario Gomez

Coach: Joachim Loew

Italy (4-3-1-2)

Gianluigi Buffon (capt); Federico Balzaretti, Andrea Barzagli, Leonardo Bonucci, Giorgio Chiellini; Andrea Pirlo, Claudio Marchisio, Daniele De Rossi; Riccardo Montolivo; Mario Balotelli, Antonio Cassano

Coach: Cesare Prandelli

Referee: Stephane Lannoy (FRA)

1750 GMT: AFP's Emmanuel Barranguet has been in touch from Warsaw: "On the streets of the city on Thursday afternoon, hundreds of Germany fans have been teasing their Italian counterparts by singing "Arrivederci Italia!" to the Seven Nation Army tune ("Po popo po popo pooooo...")

In the face of such musical mockery the 'tifosi' may as well pack up and go home...

WELCOME TO AFP'S LIVE REPORT on the second semi-final of the Euro 2012 football championships which sees Germany take on Italy for the right to play Spain in Sunday's final in Kiev.

Kick-off at the National Stadium in the Poland's capital Warsaw is just over hour away at 1845 GMT - stay with us for all the team news and build-up with input from our reporters at the game Barnaby Chesterman and Ryland James.

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Ephron blazed trail in male-dominated industry

FILE - This Nov. 3, 2010 file photo shows author, screenwriter and director Nora Ephron at her home in New York. Oscar-nominated filmmaker and author Nora Ephron is very ill, according to a representative for her publisher. Nicholas Latimer of Alfred A. Knopf confirmed her condition on Tuesday, June 26, 2012, hours after celebrity columnist and friend Liz Smith published what appeared to be a memorial for the writer. Smith told The Associated Press that she had spoken to Ephron's son Tuesday morning and was told that Ephron was dying. She said when she heard that funeral plans had already been arranged, she published the column on the website Women on the Web. Latimer did not provide any additional information on Ephron's condition. (AP Photo/Charles Sykes, file)

FILE - This Nov. 3, 2010 file photo shows author, screenwriter and director Nora Ephron at her home in New York. Oscar-nominated filmmaker and author Nora Ephron is very ill, according to a representative for her publisher. Nicholas Latimer of Alfred A. Knopf confirmed her condition on Tuesday, June 26, 2012, hours after celebrity columnist and friend Liz Smith published what appeared to be a memorial for the writer. Smith told The Associated Press that she had spoken to Ephron's son Tuesday morning and was told that Ephron was dying. She said when she heard that funeral plans had already been arranged, she published the column on the website Women on the Web. Latimer did not provide any additional information on Ephron's condition. (AP Photo/Charles Sykes, file)

LOS ANGELES (AP) ? Before Nancy Meyers, before Sofia Coppola, before Julie Delpy and Kasi Lemmons and Nicole Holofcener, there was Nora Ephron.

She was a rare woman writing and directing in what was (and still is) the male-dominated industry of filmmaking. Ephron staked out her spot on the cinematic landscape with a distinctive voice and formidable wit. Now, she leaves behind a legacy of classic moments and quotable lines after succumbing to leukemia Tuesday at age 71.

The very mention of her name calls to mind a certain kind of movie, something you can't say about many filmmakers, regardless of their gender. They were romantic comedies, yes, but ones for smart women, about smart women, with characters who had both bite and vulnerability to them. Maybe they were a tad too hyper-analytical or neurotic, but they were always highly verbal and, more often than not, destined for the kind of happy ending they deserved.

Meg Ryan forged and reinforced her status as America's Sweetheart with roles in movies Ephron either wrote or wrote and directed: The best of these was 1989's "When Harry Met Sally ..." (directed by Rob Reiner), followed by "Sleepless in Seattle" in 1993 and "You've Got Mail" in 1998, both with Tom Hanks in winning form as Ryan's likable everyman co-star.

Decades later, you can still say the line, "I'll have what she's having," and everyone will instantly know what you're talking about. That's how lasting Ephron's work has been and will remain.

Back in the late '80s and early '90s, Kathryn Bigelow was a rare fellow female filmmaker ? and since has gone on to become the only woman to win an Academy Award for best director, for "The Hurt Locker" ? but she's focused on action pictures. Barbra Streisand also tried her hand at directing around this time with "Yentl," ''The Prince of Tides" and "The Mirror Has Two Faces." But Ephron continued on and endured, for better and for worse.

If we're being honest, some of her later work didn't come close to the level of her best-known and best-loved films. "Hanging Up" from 2000, which she and sister Delia co-wrote and star Diane Keaton directed, felt shrill and slapsticky. "Bewitched" (2005), a big-screen version of the 1960s sitcom which she directed, wrote and produced, seemed like a gimmicky strain.

But her final film, 2009's "Julie & Julia," ended her career on a stronger note. Ephron directed Meryl Streep to one of her 17 Academy Award nominations for her joyous, pitch-perfect portrayal of pioneering chef Julia Child. And it was Streep who would play a version of Ephron herself in one of the earliest films she wrote, 1986's "Heartburn," based on her own scathing novel inspired by her marriage to Washington Post reporter Carl Bernstein.

Ephron was a three-time Oscar nominee for the screenplays she wrote or co-wrote for "When Harry Met Sally ..." and "Sleepless in Seattle" as well as for her first produced script, for 1983's "Silkwood," directed by friend and frequent collaborator Mike Nichols and again starring Streep in the real-life nuclear drama.

Looking back on the A-list names listed in this piece, it's a real testament to her talent that high-quality actors and filmmakers were drawn to her and wanted to be associated with her again and again. And we haven't even mentioned Billy Crystal, Carrie Fisher, Jack Nicholson, John Travolta, Steve Martin, the list goes on.

It's that kind of singularity of voice and vision that sets an example for filmmakers to come ? both male and female.

Associated Press

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Office Furniture Suppliers | Reference and Education Bioethics

Your company needs a professional image to customers, business partners and even to attract potential employees. Finding the right way for new office equipment can be an overwhelming task and scary. With all the different suppliers of office furniture, all claiming that their furniture is best for you, it can be a difficult task. The reception is one of the first potential customers and business partners will look at your office. You may not think much, but this piece of furniture to impress. This is the main reason you need a piece of the class to invest in your office. Avoid embarrassing yourself with old furniture and used no aesthetic value to offer. Relevant to your reception room is a chair for guests and other visitors waiting for an appointment. It is always important for a number of empty seats. This is particularly true in the case of overlapping arrangements, and there are a number of guests to wait in the waiting room. It would also be acceptable for business partners to squeeze in a small bank or a scramble for seats only. Choose a chair match the interior space for the aesthetic sense of harmony in the workplace. To find an item with Office Furniture Suppliers and supply stores in your area or by browsing through the websites of suppliers furniture. This is the ideal way to shop, especially if you have a tight schedule and no time to the actual shop to visit.

You will find a variety of designs and it is important to choose the components that fit into the space. Your receptionist is probably multitasking, so you have a table with lots of room to move in. Some pieces big enough for two or more receptionists and ideal for larger offices. It would also be wise to choose a reception with a provision for desktop or laptop, printer, scanner and other important digital setup. Professionalism is important in an office, and office furniture that is what should inspire. This must be an atmosphere that ensures the right amount for the convenience of institutions offer workplace, perform a clean and orderly, and focused on the organization. This is very different from how we choose our home furniture, which we tend to close around us ? our comfort, as we are, our personal identity ? that promotes relaxation and a peaceful atmosphere.

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How bacteria change movement direction in response to oxygen: Molecular interactions unravelled

Public release date: 25-Jun-2012
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Contact: Dr. Samir El-Mashtoly
samir.elmashtoly@bph.rub.de
49-234-322-9833
Ruhr-University Bochum

RUB researcher and Japanese colleagues report in the Journal of Biological Chemistry

How single cell organisms like bacteria manage to react to their environment is not yet completely understood. Together with colleagues from Japan, Dr. Samir El-Mashtoly from the RUB Department of Biophysics, led by Prof. Dr. Klaus Gerwert, has gained new insights into the molecular interactions during aerotaxis of Bacillus subtilis, i.e., the dependence of the movement direction on the oxygen concentration in the environment. The research team investigated the conformational changes within the protein HemAT. Via a signal transduction chain, this protein sends a command to the flagellar motor which controls the movement direction. They report in the Journal of Biological Chemistry.

Signal transduction chain

The signal transduction chain starts with binding of oxygen to HemAT's heme domain, which is also known from haemoglobin in the red blood cells and is called the sensor domain of HemAT. Oxygen binding leads to a conformational change in the sensor domain. This in turn provokes several further conformational changes within HemAT that finally affect the signalling domain of the protein. The signalling domain then transmits the information about a rise in oxygen concentration to other proteins within the cell. These proteins forward the message to the motor of the flagellum. The research team investigated how the information travels from the sensor domain of HemAT to its signalling domain.

Protein helices forward the information

For that purpose, Dr. El-Mashtoly used the time-resolved ultraviolet resonance Raman spectroscopic facilities in the Picobiology Institute in Japan. This method provides, for instance, structural information about the conformation of the protein and hydrogen bonding interactions on a nanosecond to microsecond time scale. The results suggest that the conformational change in the sensor domain, i.e., the heme structure, induces the displacement of two protein helices within HemAT. This displacement affects another helix which is continuous with the structure of the signalling domain. Due to a series of conformational changes, the information about oxygen binding thus reaches the signalling domain of the protein.

###

Bibliographic record

S. El-Mashtoly, M. Kubo, Y. Gu, H. Sawai, S. Nakashima, T. Ogura, S. Aono, T. Kitagawa (2012): Site-specific protein dynamics in communication pathway from sensor to signaling domain of oxygen sensor protein, HemAT-Bs, Journal of Biological Chemistry, doi: 10.1074/jbc.M112.357855

Figure online

A figure related to this press release can be found online at: http://aktuell.ruhr-uni-bochum.de/pm2012/pm00213.html.en

Further information

Dr. Samir El-Mashtoly, Department of Biophysics, Faculty of Biology and Biotechnology at the Ruhr-Universitt, 44780 Bochum, Germany, Tel. +49/234/32-29833 samir.elmashtoly@bph.rub.de

Click for more

Biophysics at RUB
http://www.bph.rub.de/index_en.htm

Editor: Dr. Julia Weiler

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 25-Jun-2012
[ | E-mail | Share ]

Contact: Dr. Samir El-Mashtoly
samir.elmashtoly@bph.rub.de
49-234-322-9833
Ruhr-University Bochum

RUB researcher and Japanese colleagues report in the Journal of Biological Chemistry

How single cell organisms like bacteria manage to react to their environment is not yet completely understood. Together with colleagues from Japan, Dr. Samir El-Mashtoly from the RUB Department of Biophysics, led by Prof. Dr. Klaus Gerwert, has gained new insights into the molecular interactions during aerotaxis of Bacillus subtilis, i.e., the dependence of the movement direction on the oxygen concentration in the environment. The research team investigated the conformational changes within the protein HemAT. Via a signal transduction chain, this protein sends a command to the flagellar motor which controls the movement direction. They report in the Journal of Biological Chemistry.

Signal transduction chain

The signal transduction chain starts with binding of oxygen to HemAT's heme domain, which is also known from haemoglobin in the red blood cells and is called the sensor domain of HemAT. Oxygen binding leads to a conformational change in the sensor domain. This in turn provokes several further conformational changes within HemAT that finally affect the signalling domain of the protein. The signalling domain then transmits the information about a rise in oxygen concentration to other proteins within the cell. These proteins forward the message to the motor of the flagellum. The research team investigated how the information travels from the sensor domain of HemAT to its signalling domain.

Protein helices forward the information

For that purpose, Dr. El-Mashtoly used the time-resolved ultraviolet resonance Raman spectroscopic facilities in the Picobiology Institute in Japan. This method provides, for instance, structural information about the conformation of the protein and hydrogen bonding interactions on a nanosecond to microsecond time scale. The results suggest that the conformational change in the sensor domain, i.e., the heme structure, induces the displacement of two protein helices within HemAT. This displacement affects another helix which is continuous with the structure of the signalling domain. Due to a series of conformational changes, the information about oxygen binding thus reaches the signalling domain of the protein.

###

Bibliographic record

S. El-Mashtoly, M. Kubo, Y. Gu, H. Sawai, S. Nakashima, T. Ogura, S. Aono, T. Kitagawa (2012): Site-specific protein dynamics in communication pathway from sensor to signaling domain of oxygen sensor protein, HemAT-Bs, Journal of Biological Chemistry, doi: 10.1074/jbc.M112.357855

Figure online

A figure related to this press release can be found online at: http://aktuell.ruhr-uni-bochum.de/pm2012/pm00213.html.en

Further information

Dr. Samir El-Mashtoly, Department of Biophysics, Faculty of Biology and Biotechnology at the Ruhr-Universitt, 44780 Bochum, Germany, Tel. +49/234/32-29833 samir.elmashtoly@bph.rub.de

Click for more

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Sales Leads: How to Create a Lead Management Process

Last updated 22 hours ago

An important part of any marketing strategy is creating a process to track and monitor new sales leads, which are people who show interest in your products and services. By setting up a basic lead management process for the leads you capture through your marketing efforts, you can keep track of where your leads are coming from and accurately measure the effectiveness of your marketing. Here are a simple few tips to get started with lead management for your business.

Track the Source of Your Leads

A vital part of the process of handling your sales leads is to make sure that you track where those leads are coming from. This task will help the overall effectiveness of your online and offline advertising efforts because you?ll have a clear understanding of which marketing tactics are driving the most customers to your business. One simple way to do this is to simply ask prospects how they heard about your business once they contact you. Additionally, you can use analytics software on your website to monitor the sources of online leads. Another option for tracking leads is to use a call tracking number or tracking URL that you can place on your offline or online advertising, so when people contact you via those methods, you can track which marketing brought them to your business. Then, you can use this insight to shift your marketing investment toward the types of efforts that bring you the most customers.

Monitor & Respond to Social Media Channels

Social media channels like Facebook, Twitter, LinkedIn, and Google Plus have become great new sources of potential leads for your business. It?s important to monitor social media regularly and follow up with consumers who are leaving comments on your page, tweeting you publicly, or sending you direct messages. If someone expresses interest in your product or service or contacts you directly via social media, ask them to contact you via email or phone so you can get more information about what they?re interested in, and collect their contact information so you can follow up. In addition, you can use social media pages as a source of information about your target market, like their demographics, interests, and expectations from your business. ?

Set Up Notifications of New Leads

To take your lead management strategy to the next level, you can invest in a service that provides real-time lead notifications, such as an email or SMS message, when you receive a new lead. New leads could be generated from a ?a form submission, email, voicemail, or chat lead. Notifications let you know as soon as a lead comes in, provide a record of the lead, and ensure you can respond promptly to close the sale.?In fact, after the first hour, the chances of reaching a lead are reduced by 10 times.?

Record Your Calls

Recording calls to your business is an easy way to track and store incoming sales leads. Many?call recording technologies?not only let you record the live call itself, but also capture data such as caller ID, date, and time, so you have a full picture of the call and caller. Plus, the ability to record calls can also provide additional business insight, such as whether or not your team is effectively answering the phone, ?trends about what customers are calling about, and issues or feedback about your products or services, so you can make adjustments where needed.

Organize Your Database

Whether you?re entering leads into a CRM system or managing them in your own spreadsheet, it?s important to?keep your lead data clean?and organized. First, determine what data you want to capture, like name, email, phone, and lead source, so that you?re always recording the same type of information for each lead. In addition, you should regularly check your list and remove duplicate leads, make sure contact information is complete and up-to-date, and keep track of all interactions with the prospect so that you can pace out how often you want to reach out again ?to existing customers and active leads you?ve already contacted.?

Once you have a solid process in place for managing new sales leads, it?s important to tie any sales you make back to the original lead to accurately measure the ultimate ROI of your marketing investment. By documenting this process, you?ll have a better idea of which marketing investments have the biggest impact on your business.?

What lead management strategies has your business implemented, and which do you plan on adding? Let us know in a comment!

Tamara?Weintraub?helps equip small business owners with information about local online advertising, social media, and content marketing as a writer for?the?ReachLocal?blog.

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Hilary Duff Served With Lawsuit After Car Accident

Lizzie McGuire star Hilary Duff has been served with a lawsuit following a car accident that took place two year ago in 2010.? Get the details behind Duff’s legal problems below. New mom Hilary Duff has been hit? with a lawsuit for a 2010 car accident.? The twenty-four year old reportedly caused major damage to a woman by the name of Rachel Olson. Olsen said in court documents that she was”hurt and injured in her health, strength and activity, sustaining injury to her nervous system,” after the crash that took place on December 12th of that year. Owens also claims, in the lawsuit papers? that were filed in L.A. County Superior Court, that her injuries stopped her from finishing her job requirements.? Stating, that after being hit by Duff in her Range Rover it prevented her from “attending her usual occupation for a period of time in the future.” Olsen filed the complaint against the actress seeking unspecified damages.? Hilary Duff and her reps have yet to comment on the matter. In other news, the wife of pro hockey player Mike Comrie and new mom to Luca Cruz Comrie was also questioned by fans after a photo of Duff holding [...]

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06/25/2012 - Using Google Docs in the Classroom

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Shooting survivor holds 'Congress on Your Corner'

FILE - In this Tuesday, June 12, 2012 file photo, former Rep. Gabrielle Giffords, D-Ariz., stands with candidate Ron Barber as they celebrate his victory in an election to fill her seat in Tucson, Ariz. Giffords' former district director ran in a special election for the seat she left in January to focus on her recovery from a gunshot wound to the head during a gunman's shooting spree a year earlier. The newly sworn-in congressman, who was also injured in the shooting, held the first "Congress on Your Corner" event in the southern Arizona district on Saturday, June 23, 2012 since the incident. (AP Photo/Ross D. Franklin, Pool)

FILE - In this Tuesday, June 12, 2012 file photo, former Rep. Gabrielle Giffords, D-Ariz., stands with candidate Ron Barber as they celebrate his victory in an election to fill her seat in Tucson, Ariz. Giffords' former district director ran in a special election for the seat she left in January to focus on her recovery from a gunshot wound to the head during a gunman's shooting spree a year earlier. The newly sworn-in congressman, who was also injured in the shooting, held the first "Congress on Your Corner" event in the southern Arizona district on Saturday, June 23, 2012 since the incident. (AP Photo/Ross D. Franklin, Pool)

U.S. Rep. Ron Barber, D-Ariz., center, meets with constituents Jim Tucker, left, and his wife Doris who are the first in line to greet him during a "Congress On Your Corner" event at a grocery store on the corner of North Craycroft and East Grant Roads in Tucson, Ariz. on Saturday, June 23, 2012. The Tuckers were also one of the first people in line when Rep. Gabrielle Giffords was shot and wounded and six people were killed outside a supermarket on Jan. 11, 2011. Sworn into office earlier in the week, this is the first such event in Congressional District 8 since the shooting. Barber, who was Giffords' district director at the time, was also wounded during the shooting. (AP Photo/Arizona Daily Star, A.E. Araiza) MANDATORY CREDIT: ARIZONA DAILY STAR, A.E. ARAIZA

TUCSON, Ariz. (AP) ? A newly sworn-in congressman who was injured in a mass shooting last year along with then-Rep. Gabrielle Giffords held his first "Congress on Your Corner" event with southern Arizona constituents on Saturday.

Giffords conducted 21 of the informal meet-and-greet events during her more than four years in office, including one on the day of the shooting ? Jan. 8, 2011. The rampage left six dead and 13 wounded, including Giffords and her then-district director, Ron Barber.

Giffords relinquished the seat in January to concentrate on her recovery from a gunshot wound to the head. Barber, a Democrat, won a special election to replace her earlier this month. He was sworn in Tuesday in Washington, D.C.

About 300 people showed up at Saturday's event outside a Tucson grocery store as temperatures topped 100 degrees, Barber spokesman Mark Kimble said. Visitors ranged from other survivors of the mass shooting and well-wishers to people who had concerns about their federal student loans or veteran's benefits, he said.

The event had been scheduled to last an hour and a half.

"But there were so many people, we went three hours," Kimble said.

Jared Lee Loughner has pleaded not guilty to 49 charges stemming from the shooting, which took place in front of another Tucson grocery store.

Barber was shot twice ? once in the face and once in the leg. He was asked by Giffords earlier this year to pursue the seat, and she appeared in Tucson during the campaign's final days to help him.

Barber defeated Republican Jesse Kelly, who narrowly lost to Giffords in 2010.

Associated Press

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How to convert MXF to iPad/iPad 2 with MXF to iPad Converter for Mac?

How to convert MXF to iPad/iPad 2 with MXF to iPad Converter for Mac?

Mac MXF to iPad Converter - How to convert MXF to iPad/iPad 2 with MXF to iPad Converter for Mac?

Do you want to convert MXF to iPad/iPad 2 to share the MXF videos with friends and family? But do you know why should you convert MXF to iPad on Mac?

It's clear that MXF encoded with any of a variety of codecs, together with a metadata wrapper which describes the material contained within the MXF file. iPad doesn't support MXF files format, so the most important is convert MXF to iPad/iPad 2 on Mac.

Mac MXF to iPad Converter is such a program which enables you convert MXF to iPad recongniaed video format like MP4 so that you can transfer MXF files into iPad/iPad 2 successully on Mac. With it you can also convert MXF to other popular video format like MOV, WMV, AVI, 3GP, etc.

After converting MXF to iPad on Mac, you can import converted MXF files into iPad or iPad 2 for sharing. And if you like, to make your video special, MXF to iPad Converter for Mac allows you use its editing functions like merge videos, trim and crop video, add watermark, etc.

Below is the fast guide for you to convert MXF to iPad/iPad 2 on Mac.

Step 1. Add MXF files into this MXF to iPad Converter for Mac

After downloading and running this program, click "Add" button to load the MXF files into the MXF to iPad Converter Mac.

Step 2. Select output format

You can click on the "Format? bar, follow the list, you can choose the video formats like ".mov", then click the "Browse? button next to "Export to? field and specify an output folder to save converted files. Click "Choose? to confirm.

Step 3. Start convert

Before converting MXF to iPad on Mac, you can set video and audio bit rate, frame rate, channels, etc to make your videos different from others. All things are ready, you click "Convert" button to convert MXF to iPad on Mac.

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?Blue Water Pools? : Construct your dream swimming pool

Today, it is not important when or where swimming pools are, what is most important is that swimming pools became an essential part of our lives. Swimming pools are so popular and have countless benefits in our day-to-day life. Just the feeling of be

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Today, it is not important when or where swimming pools are, what is most important is that swimming pools became an essential part of our lives. Swimming pools are so popular and have countless benefits in our day-to-day life. Just the feeling of being soaked in warm water at the end your hectic day gives you the power to get rid of tensions and worries. Swimming pools are nowadays, most commonly found in the backyard of the house and add beauty to the surroundings.

Constructing a swimming pool in your backyard is like adding a value to your house. One can relax there after hectic schedule or can organize a pool party to enjoy with their friends. It is essential to contact a reliable contractor for swimming pool construction. If you want to give a recreational gift to your family, then "Blue Water Pools" are the best choice amongst other pool constructors. "Blue Water Pools" are the family owned business setup in 1984 and serving several states such as New Mexico, Santa Fe, Clovis, Las Vegas and many more. We deliver the best quality swimming pools for residential area and offer various services include swimming pool design, layout, excavation, electrical and plumbing, as well as start-up training and over all maintenance. Santa Fe swimming pool construction is done at great scale to satisfy our customer's needs and requirements.

Our well-trained and skilled team offers various services like new pool construction, swimming pool renovation or remodeling and more. Our experience in this field is the trademark of our success and reputation and we provide more services at lesser price, which no other swimming pool builder can afford to provide. We will construct a swimming pool that match the surroundings and landscapes and gives the appealing look to your backyard.

If you think that your pool is little out dated, does not match the surroundings of your house or it needs some extra care, then you can contact us anytime and enjoy the remodeling services. Swimming pool remodeling Roswell is a simple face-lift or anything your pool needs, we update the pool and gives a stunning new look. We provide unmatched services at a very competitive price.

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DOJ files bias suit against towns home to polygamist sect

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Consumer bureau discloses credit-card complaints - eShareholder

By Alwyn Scott and Rick Rothacker

(Reuters) - Consumers shopping for a credit card can see for the first time, starting on Tuesday, how many complaints issuers have received before picking their plastic.

The U.S. Consumer Financial Protection Bureau unveiled a complaint database on its web site in one of the agency's more high-profile moves since it was created under the Dodd-Frank financial reform act.

While the initial release of figures was limited, covering less than a month, it created a ranking among credit card issuers that could leave some uncomfortable. Capital One Financial Corp (COF) tallied the most complaints since June 1.

The decision to disclose complaints drew fire from financial industry groups, which said the law does not authorize the agency to release the data publicly, that it is not verified and that complaint rates by zip code are trade secrets that should be kept private.

The CFPB disagreed, saying the law authorized the disclosures and, while it does not verify each complaint, it does check whether the consumer has a relationship with the institution.

"Consumers can look at this data and can fairly draw the conclusion that if they engage in a financial relationship with the company this is what they can expect," said Scott Pluta, acting assistant director of the Office of Consumer Response of the CFPB, which only opened its doors in July 2011.

The database, available at consumerfinance.gov, is small, showing only 137 complaints collected since June 1. But over the next year, that number is likely to grow substantially.

The agency actually began collecting complaints nearly a year ago and has received more than 16,800 of them. It plans to expand the database to include these complaints in coming months and to add complaints about mortgages and other financial services, Pluta said. The earlier data contained different fields and so was not directly comparable to the data collected since June 1.

LEAGUE TABLE

The data released on Tuesday shows Capital One received the most complaints, 33, followed by Citigroup Inc (NYS:C) with 27, JPMorgan Chase & Co (JPM) with 24 and Bank of America Corp (BAC) with 15.

Capital One topped the list despite being fifth in purchase volumes in 2011, according to rankings compiled by The Nilson Report, an industry publication. American Express Co (AXP), which had only six complaints, had the largest market share with 25 percent, followed by JPMorgan, Bank of America and Citigroup.

"We always welcome customer feedback - good and bad - as we're always focused on continuous improvement and providing a great customer experience," said Capital One spokeswoman Tatiana Stead.

A Bank of America spokeswoman said the bank's objective is to work with customers to resolve any issues they have, and Citigroup said it has been actively responding to all customer complaints, including those fielded by the CFPB. JPMorgan declined to comment.

Kenneth Clayton, the American Bankers Association's executive vice president of legislative affairs and chief counsel, said the banking industry is ready to work with the CFPB to resolve consumer complaints but called the release of the database disappointing and potentially misleading to consumers.

"Publicizing allegations that may or may not have any basis in fact raises serious questions about the balanced review we expect from our government agencies," he said in a statement.

Consumers Union, the policy and advocacy division of Consumer Reports, praised the CFPB's decision to make the database public and said it supported expanding the database to include complaints about other financial products.

"Making credit card complaints public will put added pressure on banks to avoid unfair practices and help consumers make more informed financial decisions," said Pamela Banks, senior policy counsel for Consumers Union, in a statement.

The credit card companies are required to respond within 15 days and to close the complaint with an action in 60 days, Pluta said. Banks that don't respond in time are tagged in the database. So far, only one of the 137 complaints had not received a timely response. It involved Bank of America and a request to close or cancel an account.

Pluta said the agency takes steps to stop people from gaming the system. Entries must be complete and must involve a bank the bureau supervises. If the complaint is a duplicate, the agency merges it with the original. And the agency verifies that the complainant has a relationship with the bank in question, although it can't verify the merits of the complaint. Also, the form takes time to fill out and consumers must attest that the information is true.

The agency is open to working with banks to improve controls to avoid manipulation.

"So far, we've been open 11 months and there are no suspected cases of widespread manipulation," Pluta said.

(Additional reporting by Cezary Podkul; Editing by Edmund Klamann)

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justaddwater.dk | Jim Webber on qCon New York

Please help me choose the best photos I took during Jim Webbers talk at qCon New York.

You can do me a favor and vote (max 3 votes per person).

License: Creative commons (attribution).

This entry was posted by Jesper R?nn-Jensen on Wednesday, June 20th, 2012 at 22:07 (GMT-1) and is filed under Events/seminars, QCon. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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Inflation drops to 2.8% as oil prices slide

Iraqi workers are seen at the Rumaila oil refinery, near the city of Basra. A fall in oil prices has taken the heat out of inflation. Photograph: Nabil Al-Jurani/AP

Inflation has slipped to its lowest level in two and a half years, in a rare piece of good news for Britain's recession-hit households.

The Office for National Statistics said the annual inflation rate, measured on the consumer price index, slipped to 2.8% last month from 3% in April, as falling oil prices fed through to cheaper petrol at the pump.

The ONS cited motor fuels as the biggest factor, with petrol prices falling by 4.5p a litre in a single month, to stand at ?1.37.

During May, the cost of a barrel of Brent crude oil on international markets slipped from $120 to $103. It has since fallen further, to $83.

On the retail price index measure, which also includes housing costs, inflation slipped to 3.1% in May from 3.5% a month earlier.

Though inflation is still well above the Bank of England's target of 2%, the fall should help to reassure policymakers that they can take more action to stimulate the economy without sparking a renewed surge in prices.

The Bank of England governor, Sir Mervyn King, hinted in his Mansion House speech last week that the monetary policy committee could unleash a fresh bout of quantitative easing - electronic money creation - alongside the government's new measures for kickstarting credit.

Jeremy Cook, of the currency broker World First, said the data "will trigger a sigh of relief from Threadneedle St" as it gives the Bank further leeway with possible further expansionary monetary policy, such as interest rate cuts or additional asset purchases.

Some members of the Bank's monetary policy committee (MPC) have previously expressed caution about more QE, warning that it could push up inflation, but world commodity prices have been falling in recent weeks amid fears about a slowdown in the world economy. Wednesday's minutes from the MPC's June meeting will show whether any members were calling for more QE.

The ONS said food and non-alcoholic drink prices rose by 0.3% between April and May, compared with a 1.3% increase a year ago, meaning that food prices also contributed to the downward slide in inflation.

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Put some further self improvement link to your internet site

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